OrangerV1, France, Analysis, bibRecord, 000162

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.

Identifieur interne : 000162 ( France/Analysis ); précédent : 000161; suivant : 000163

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.

Auteurs : C. Bayet [France] ; C. Fazio [France] ; N. Darbour [France] ; O. Berger [France] ; I. Raad [France] ; A. Chaboud [France] ; C. Dumontet [France] ; D. Guilet [France]

Source :

RBID : Hal:hal-00314988

Abstract

Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.

Url:

https://hal.archives-ouvertes.fr/hal-00314988

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000014
to stream Hal, to step Curation: 000014
to stream Hal, to step Checkpoint: 000018
to stream Main, to step Merge: 002596
to stream Main, to step Curation: 002501
to stream Main, to step Exploration: 002501
to stream France, to step Extraction: 000162

Links to Exploration step

Hal:hal-00314988

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.</title>
<author><name sortKey="Bayet, C" sort="Bayet, C" uniqKey="Bayet C" first="C." last="Bayet">C. Bayet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Fazio, C" sort="Fazio, C" uniqKey="Fazio C" first="C." last="Fazio">C. Fazio</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Darbour, N" sort="Darbour, N" uniqKey="Darbour N" first="N." last="Darbour">N. Darbour</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Berger, O" sort="Berger, O" uniqKey="Berger O" first="O." last="Berger">O. Berger</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Raad, I" sort="Raad, I" uniqKey="Raad I" first="I." last="Raad">I. Raad</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Chaboud, A" sort="Chaboud, A" uniqKey="Chaboud A" first="A." last="Chaboud">A. Chaboud</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Dumontet, C" sort="Dumontet, C" uniqKey="Dumontet C" first="C." last="Dumontet">C. Dumontet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Guilet, D" sort="Guilet, D" uniqKey="Guilet D" first="D." last="Guilet">D. Guilet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00314988</idno>
<idno type="halId">hal-00314988</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00314988</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00314988</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Hal/Corpus">000014</idno>
<idno type="wicri:Area/Hal/Curation">000014</idno>
<idno type="wicri:Area/Hal/Checkpoint">000018</idno>
<idno type="wicri:Area/Main/Merge">002596</idno>
<idno type="wicri:Area/Main/Curation">002501</idno>
<idno type="wicri:Area/Main/Exploration">002501</idno>
<idno type="wicri:Area/France/Extraction">000162</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.</title>
<author><name sortKey="Bayet, C" sort="Bayet, C" uniqKey="Bayet C" first="C." last="Bayet">C. Bayet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Fazio, C" sort="Fazio, C" uniqKey="Fazio C" first="C." last="Fazio">C. Fazio</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Darbour, N" sort="Darbour, N" uniqKey="Darbour N" first="N." last="Darbour">N. Darbour</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Berger, O" sort="Berger, O" uniqKey="Berger O" first="O." last="Berger">O. Berger</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Raad, I" sort="Raad, I" uniqKey="Raad I" first="I." last="Raad">I. Raad</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Chaboud, A" sort="Chaboud, A" uniqKey="Chaboud A" first="A." last="Chaboud">A. Chaboud</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Dumontet, C" sort="Dumontet, C" uniqKey="Dumontet C" first="C." last="Dumontet">C. Dumontet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Guilet, D" sort="Guilet, D" uniqKey="Guilet D" first="D." last="Guilet">D. Guilet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-581" status="OLD"><orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
<orgName type="acronym">IBCP</orgName>
<desc><address><addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ibcp.fr</ref>
</desc>
<listRelation><relation active="#struct-194495" type="direct"></relation>
<relation name="UMR5086" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"><orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc><address><addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5086" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lyon</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université de Lyon</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bayet, C" sort="Bayet, C" uniqKey="Bayet C" first="C." last="Bayet">C. Bayet</name>
</region>
<name sortKey="Berger, O" sort="Berger, O" uniqKey="Berger O" first="O." last="Berger">O. Berger</name>
<name sortKey="Chaboud, A" sort="Chaboud, A" uniqKey="Chaboud A" first="A." last="Chaboud">A. Chaboud</name>
<name sortKey="Darbour, N" sort="Darbour, N" uniqKey="Darbour N" first="N." last="Darbour">N. Darbour</name>
<name sortKey="Dumontet, C" sort="Dumontet, C" uniqKey="Dumontet C" first="C." last="Dumontet">C. Dumontet</name>
<name sortKey="Fazio, C" sort="Fazio, C" uniqKey="Fazio C" first="C." last="Fazio">C. Fazio</name>
<name sortKey="Guilet, D" sort="Guilet, D" uniqKey="Guilet D" first="D." last="Guilet">D. Guilet</name>
<name sortKey="Raad, I" sort="Raad, I" uniqKey="Raad I" first="I." last="Raad">I. Raad</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000162 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000162 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Bois
   |area=    OrangerV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-00314988
   |texte=   Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.
}}

This area was generated with Dilib version V0.6.25.
Data generation: Sat Dec 3 17:11:04 2016. Site generation: Wed Mar 6 18:18:32 2024

	Serveur d'exploration sur l'oranger
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur l'oranger

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri